ABSTRACT
ABSTRACT Introduction With the normalization of the prevention and control of the covid-19 epidemic, the proportion of outdoor sports in sports has gradually increased, but the risks have increased, resulting in joint injuries. Objective Explore the prevention of joint injuries in outdoor sports under the influence of covid-19. Methods 88 men and 64 women with ankle injuries, 45 men and 33 women with knee injuries, for a total of 133 men and 97 women volunteers were investigated by questionnaire, which included joint injuries, causes of injuries, and treatment methods after joint injuries, and the data were analyzed. Results Currently, most joint injuries in outdoor sports belong to minor injuries, which can recover after some minor readjustments and will not cause much impact on the sportsmen. However, there are also some serious injuries. Conclusion The athletes themselves must be fully prepared, including the use of protective gear and equipment, psychological adjustment, and learning knowledge about sports protection. Coaches and volunteers should give scientifically based and sensible guidance according to the actual situation of the sportsmen to reduce the incidence of joint injuries as much as possible. Level of Evidence II; Therapeutic studies - investigation of treatment outcomes.
RESUMO Introdução Com a normalização da prevenção e controle da epidemia de covid-19, a proporção de esportes ao ar livre no esporte tem aumentado gradualmente, mas os riscos têm aumentado, resultando em lesões articulares. Objetivo Explorar a prevenção de lesões nas articulações em esportes ao ar livre sob a influência da covid-19. Métodos 88 homens e 64 mulheres com lesões no tornozelo, 45 homens e 33 mulheres com lesões no joelho, num total de 133 homens e 97 mulheres voluntárias foram investigados por questionário, que incluiu lesões nas articulações, causas de lesões e métodos de tratamento após lesões nas articulações, tendo os dados sido analisados. Resultados Atualmente, a maioria das lesões nas articulações em esportes ao ar livre pertencem a lesões menores, que podem recuperar-se após alguns pequenos reajustes, o que não causará muito impacto nos esportistas, porém há também algumas lesões graves. Conclusão Os próprios esportistas devem estar totalmente preparados, incluindo o uso de aparelhos e equipamentos de proteção, o ajuste psicológico e o aprendizado dos conhecimentos sobre proteção esportiva. Os treinadores e voluntários devem dar orientações cientificamente fundamentadas e sensatas de acordo com a situação real dos praticantes do esporte, a fim de reduzir ao máximo a incidência de lesões articulares. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.
RESUMEN Introducción Con la normalización de la prevención y el control de la epidemia del covid-19, la proporción de deportes al aire libre en el deporte ha aumentado gradualmente, pero los riesgos han aumentado, dando lugar a lesiones articulares. Objetivo Explorar la prevención de lesiones articulares en deportes al aire libre bajo la influencia del covid-19. Métodos 88 hombres y 64 mujeres con lesiones de tobillo, 45 hombres y 33 mujeres con lesiones de rodilla, un total de 133 hombres y 97 mujeres voluntarios fueron investigados mediante un cuestionario, que incluía las lesiones articulares, las causas de las lesiones y los métodos de tratamiento después de las lesiones articulares, y se analizaron los datos. Resultados En la actualidad, la mayoría de las lesiones articulares en los deportes al aire libre pertenecen a lesiones menores, que pueden recuperarse tras unos pequeños reajustes, que no causarán mucho impacto en los deportistas, sin embargo, también hay algunas lesiones graves. Conclusión Los propios deportistas deben estar totalmente preparados, incluyendo el uso de equipos de protección, la adaptación psicológica y el aprendizaje de los conocimientos sobre protección deportiva. Los entrenadores y los voluntarios deben dar orientaciones con base científica y sensatas, de acuerdo con la situación real de los deportistas, para reducir al máximo la incidencia de las lesiones articulares. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.
ABSTRACT
Background: Previous studies revealed that liver injury is common in the novel coronavirus disease 2019 (COVID-19) patients. However, risk factors of liver injury and whether liver injury is related to the severity or prognosis of COVID-19 is unclarified. Methods: COVID-19 patients were retrospectively recruited from a tertiary hospital in Wuhan, China. General information, past medical history, symptoms, signs, laboratory examination results and clinical outcomes were collected. Incidence and potential risk factors of liver injury were analyzed. Laboratory examination results, incidence of other symptoms and the incidence of the main outcomes, disease progression and death, were compared between patients with or without liver injury. Findings: About 57·7% patients showed liver injury. The incidence of liver injury was higher in male patients. More patients with liver injury were diagnosed as critically ill at admission. Patients with liver injury had higher incidence of dyspnea, lower SpO2 and higher maximum body temperature. They also had many worse laboratory examination results regarding inflammation, cytokines, renal function, coagulation function and myocardial injury. And, the incidence of disease progression and mortality was much higher in patients with liver injury. In further multivariable logistic analysis, direct bilirubin, hs-CRP and NT-proBNP were independent predictors for disease progression, and chronic pulmonary disease, hemoptysis, cholesterol and IL-2R were independent predictors for death. Interpretation: Liver injury is common in COVID-19 patients, and male patients are at higher risk to have liver injury. Patients with liver injury can be severer and have a higher incidence of disease progression than those without. Funding: The present study was not supported by any funding.Declaration of Interests: All the authors declare no conflicts of interests.Ethics Approval Statement: The study protocol is approved by the Institutional Ethics Committee of Peking University First Hospital and all the methods were carried out in accordance with the approved guidelines of the committee and with the Helsinki Declaration. Informed consent is waived.
Subject(s)
Coronavirus Infections , Lung Diseases , Dyspnea , Hemoptysis , COVID-19 , Cardiomyopathies , Liver DiseasesABSTRACT
Patients with COVID-19 frequently manifest coagulation abnormalities and thrombotic events. In this meta-analysis, we aimed to explore the role of coagulopathy on the severity differences in patients with COVID-19. We conducted systematic literature search via Pubmed, Embase, Cochrane, WanFang Database, CNKI, and medRxiv from December 1, 2019 to May 1, 2020, to identify all original studies that reports on coagulation parameters (D-dimer, PLT, PT, APTT, and FIB) during COVID-19 infection. Thereafter, we compared the coagulation parameters between less severe and more severe cases. All Statistical analyses were performed via Stata14.0 software. A total of 3,952 confirmed COVID-19 infected patients were included from 25 studies. Patients with severe COVID-19 infection exhibited significantly higher levels of D-dimer, PT, and FIB (SMD 0.83, 95% CI: 0.70-0.97, I2 56.9%; SMD 0.39, 95% CI: 0.14-0.64, I2 77.9%; SMD 0.35, 95% CI: 0.17-0.53, I2 42.4% respectively). However, difference in PLT and APTT levels between less severe and more severe patients was not statistically significant (SMD-0.26, 95% CI: -0.56-0.05, I2 82.2%; SMD-0.14,95% CI: -0.45-0.18, I2 75.5% respectively) This meta-analysis revealed coagulopathy is associated with the severity of COVID-19. Notably, D-dimer, PT, and FIB are the dominant parameters that should be considered in evaluating coagulopathy in COVID-19 patients.
Subject(s)
Coronavirus Infections , Infections , Blood Coagulation Disorders , Thrombosis , COVID-19 , Coagulation Protein DisordersABSTRACT
Background and objective: Coronavirus disease (COVID-19) is currently an urgent global issue, but we cannot ignore the impact of influenza A since there is an overlap of infection time and region and similar clinical manifestations and chest computed tomography (CT) images for influenza A and COVID-19 infections. We compared patients who had a COVID-19 infection and co-infection with the influenza A virus.Methods: We retrospectively reviewed patients who met the inclusion criteria for this study.Results: There were 213 patients included in this study, of whom 106 were females and 107 were males, with a median age of 63 years. All patients were diagnosed with COVID-19 and were subsequently divided into influenza positive (n = 97) and influenza negative (n = 116) groups according to the serum test results for the influenza A IgM antibody. The two groups had similar symptoms, outcomes, CT manifestation and CT scores, except for lymphadenopathy (6.2% in the influenza positive group vs. 14.7% in the negative group, P = 0.047). However, in the subgroup analysis, male or younger patients (age <= 60 years) in the influenza negative group had higher CT scores than patients in the influenza positive group (P < 0.05).Conclusions: COVID-19 patients who had co-infection with the influenza A virus showed similar symptoms, outcomes, CT manifestation and CT scores to influenza negative patients. However, male patients and younger patients had higher CT scores in the influenza negative group.
Subject(s)
COVID-19 , Coinfection , Lymphatic DiseasesABSTRACT
The population is commonly susceptible to the 2019 novel coronavirus(2019-nCoV), especially the elderly with comorbidities.Elderly patients infected with 2019-nCoV tend to have higher rates of severe illnesses and mortality.Immunoaging is an important cause of severe novel coronavirus pneumonia(NCP)in the elderly.Due to the combination of underlying diseases, elderly patients may exhibit a typical manifestations in clinical symptoms, supplementary examinations and pulmonary imaging, deserving particular attention.The general condition of the elderly should be considered during diagnosis and treatment.In addition to routine care and measures such as oxygen therapy, antiviral therapy and respiratory support, treatment of underlying disease, nutritional support, sputum expectoration, complication prevention and psychological support should also be considered for elderly patients.Based on literature review and expert panel discussion, we drafted the Key Points for the Prevention and Treatment of the Novel Coronavirus Pneumonia in the elderly, aiming to provide help with the prevention and treatment of NCP and the reduction of harm to the elderly population.